The Coolest Cardiac Ablation Technologies
Adagio's portfolio is based on ultra-low temperature cryoablation (ULTC) designed to produce large, durable lesions extending through the depth of both diseased and healthy cardiac tissue., by itself, or with the added benefit of cardiac electroporation (Pulsed Field Cryoablation or PFCA).
FUNDAMENTALS OF ULTCFUNDAMENTALS OF PFCA
Adagio Medical's proprietary Pulsed Field Cryoablation is a unique combination of ULTC followed immediately by Pulsed Field Ablation (link), using the same catheter. Physiologically, the short-duration ULTC coats the catheter with ice and pre-freezes targeted myocardial tissue, focusing pulsed electric field to the frozen areas, and reducing aberrant electric currents elsewhere. Clinically, this translates into the prevention of skeletal muscle contraction, phrenic nerve capture, and microbubbles. The ice-coated catheter allows us to deliver higher voltage pulses without those unwanted effects. Furthermore, ULTC promotes stable tissue contact and lesion contiguity without the need for catheter repositioning.
The use of PFCA for treatment of cardiac arrhythmia is being evaluated in the early feasibility clinical trial.
The use of PFCA for treatment of cardiac arrhythmia is being evaluated in the early feasibility clinical trial.
